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Expressions and clinical significances of microRNA-126 and microRNA-7 in esophageal squamous cell carcinoma / 国际肿瘤学杂志
Journal of International Oncology ; (12): 936-940, 2013.
Artigo em Chinês | WPRIM | ID: wpr-439962
ABSTRACT
Objective To detect the expressions of microRNA-126 (miR-126) and microRNA-7 (miR-7) in esophageal squamous cell carcinoma (ESCC) and to analyze their correlations with clinicopathologic features and prognosis of ESCC.Methods The expressions of miR-126 and miR-7 in 116 ESCC samples and matched normal tissue samples were detected by real-time PCR.Statistical analysis was used to find the relationships among the expressions of miR-126 and miR-7,pathological characteristics and prognosis.Results Low expression,normal expression and high expression of miR-126 were found in 73 (62.9%),35 (30.2%) and 8 (6.9%) carcinoma samples respectively.Low expression,normal expression and high expression of miR-7 were found in 52 (44.8%),35 (30.2%) and 29 (25.0%) carcinoma samples respectively.The disease-free survival in patients with low expression of miR-126 and miR-7 was shorter than that in patients with non-low expression (x2 =4.268,P <0.05 ; x2 =4.993,P <0.05).The low expression of miR-126 was correlated with tumor location,family history and drinking (x2 =14.564,P < 0.05 ; x2 =5.691,P < 0.05 ; x2 =4.971,P < 0.05),but was uncorrelated with gender,age,diferentiation,infiltration,lymphatic metastasis and smoking (all P > 0.05).The low expression of miR-7 was uncorrelated with pathological characteristics of ESCC (all P > 0.05).Conclusion The low expressions of miR-126 and miR-7 may be related to the prognosis of patients with ESCC,and have a certain clinical detection significance.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Tipo de estudo: Estudo prognóstico Idioma: Chinês Revista: Journal of International Oncology Ano de publicação: 2013 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Tipo de estudo: Estudo prognóstico Idioma: Chinês Revista: Journal of International Oncology Ano de publicação: 2013 Tipo de documento: Artigo