Bio-artificial dura mater in repair of dural defects / 中国组织工程研究

ABSTRACT

BACKGROUND:Repairing integrity of the dura mater is very important for the prognosis of patients with convex meningioma. OBJECTIVE:To investigate the application value of bio-artificial dura mater on giant convex meningioma. METHODS:The retrospective analysis of 56 cases of dural defects due to tumor erosion in patients with giant convex meningioma was carried out. Meanwhile, the clinical efficacy, complications and fol ow-up results of the repair with artificial dura mater were analyzed. RESULTS AND CONCLUSION:Except two cases complicated with local effusion, one case with a smal volume of subdural effusion in operative side, one case with tardive epidural hematoma, the remaining patients had no cerebrospinal fluid leakage, intracranial infection, epilepsy, tissue rejection and other adverse reactions. Postoperative CT and MR examinations confirmed the site of implantation of artificial dura without abnormal radiographic changes. Five patients underwent cranioplasty of skul repair in 3 months postoperatively, and the intraoperative findings showed that the artificial dura mater had a good fusion with normal dura mater, with no adhesions and inflammatory reactions. These findings indicate that bio-artificial dura mater can reshape the original anatomical level, protect the cerebral cortex, and reduce the incidence of various complications significantly.