Association of the Catechol-o-Methyltransferase Gene Polymorphisms with Korean Autism Spectrum Disorders
Journal of Korean Medical Science
;
: 1403-1406, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-44040
ABSTRACT
This study evaluated the family-based genetic association between autism spectrum disorders (ASDs) and 5 single-nucleotide polymorphisms (SNPs) in the catechol-o-methyltransferase gene (COMT), which was found among 151 Korean ASDs family trios (dominant model Z = 2.598, P = 0.009, P(FDR) = 0.045). We found a statistically significant allele transmission or association in terms of the rs6269 SNP in the ASDs trios. Moreover, in the haplotype analysis, the haplotypes with rs6269 demonstrated significant evidence of an association with ASDs (additive model rs6269-rs4818-rs4680-rs769224 haplotype P = 0.004, P(FDR) = 0.040). Thus, an association may exist between the variants of the COMT gene and the occurrence of ASDs in Koreans.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Haplótipos
/
Catecol O-Metiltransferase
/
Desequilíbrio de Ligação
/
Transtornos Globais do Desenvolvimento Infantil
/
Polimorfismo de Nucleotídeo Único
/
Povo Asiático
/
Alelos
/
República da Coreia
/
Genótipo
Tipo de estudo:
Estudo prognóstico
Limite:
Criança
/
Criança, pré-escolar
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Journal of Korean Medical Science
Ano de publicação:
2013
Tipo de documento:
Artigo
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