Relationship between angiontensin Ⅱ type2-receptor gene polymorphism and essential hypertension in men / 基础医学与临床
Basic & Clinical Medicine
;
(12): 280-283, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-440614
ABSTRACT
Objective To investigate the relationship between AT2-receptor 1675A/G gene polymorphism and essential hypertension in men.Methods The 113 EH male patients and 101 controls were born in Jining.The 1675A/G polymorphism of AGTR2 gene was detected by PCR,HRM and gene sequencing.Results There was difference in genetypes(AA,GG) distribution and allele frenqency of AGTR2 1675A/G between male EH and control group (P<0.05).Genotypes(AA,GG) distribution in EH group[56(49.6%) and 57(50.4%)]are significantly higher than that in control group [32 (31.7%) and 69 (68.3%)](P<0.05).Allele frenqency in EH group[A112(49.6%) and G114(50.4%)]is significantly higher than that in control group[64(31.7%) and 138(68.3%)](P<0.05).Conclusion The 1675A/G polymorphism of AGTR2 gene may be associated with male EH in Jining area,Shandong province.
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DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Basic & Clinical Medicine
Ano de publicação:
2010
Tipo de documento:
Artigo
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