Association Between IL-13 Polymorphism (-1512A/C) and Atopic Dermatitis in Korean Children / 소아알레르기및호흡기학회지
Pediatric Allergy and Respiratory Disease
;
: 126-132, 2005.
Artigo
em Coreano
| WPRIM
| ID: wpr-44225
ABSTRACT
PURPOSE:
Interleukin (IL) -13 plays a pivotal role in the induction of immunoglobulin E (IgE) and in the pathogenesis of atopic dermatitis (AD). Recently, an association was reported between the polymorphism of the IL-13 promoter region (-1512A/C) and atopic asthma. We investigated the association between the IL-13 single nucleotide polymorphism (SNP) in the promoter region (-1512A/C) and atopic dermatitis in Korean children with AD.METHODS:
We enrolled 204 allergic AD, 92 non-allergic AD, and 116 non-atopic healthy children. Evaluated phenotypes of atopic dermatitis included total IgE, total eosinophil count, and eosinophil fraction. We used a PCR-RFLP method to identify IL-13 genotypes.RESULTS:
The allele frequencies of the IL-13 promoter polymorphism (-1512A/C) did not differ statistically among the three groups. Children with one or two copies of risk alleles in the promoter region (-1512C) did not show any significant association with the clinical phenotypes of atopic dermatitis including total IgE, eosinophil phenotypes and SCORAD score in the allergic or non-allergic atopic dermatitis.CONCLUSION:
These data suggest that the -1512A/C polymorphism of IL-13 gene may not be associated with neither the development nor the clinical phenotypes of atopic dermatitis in Korean children.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fenótipo
/
Asma
/
Imunoglobulina E
/
Imunoglobulinas
/
Interleucinas
/
Regiões Promotoras Genéticas
/
Interleucina-13
/
Polimorfismo de Nucleotídeo Único
/
Dermatite Atópica
/
Alelos
Limite:
Criança
/
Humanos
Idioma:
Coreano
Revista:
Pediatric Allergy and Respiratory Disease
Ano de publicação:
2005
Tipo de documento:
Artigo
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