Detection and analysis of the electrogastrogram and gastric emptying in functional dyspepsia patients / 中国医师进修杂志

ABSTRACT

Objective To investigate the correlation between electrogastrogram and gastric emptying in functional dyspepsia (FD) patients.Methods Fifty-one patients with FD were detected by polygraf ID 4-channel electrogastrogram(EGG) analysis system and solid radiopaque marker 5 h after a solid meal.Results 31.4％ (16/51) patients showed delayed gastric emptying(GE),and 72.5％(37/51) patients showed abnormal EGG.The rate of GE between normal EGG patients and abnormal EGG patients had no significant difference(P ＞ 0.05).In patients who had both abnormal EGG and delayed GE,EGG abnormality mainly exhibited dysrhythmia and the dominant frequency of EGG was normal.Some patients also exhibited non enhanced postprandial dominant power.The rate of GE among mild,moderate and severe symptom patients had no significant difference (P ＞ 0.05).The rate of abnormal EGG in severe symptom patients was significantly higher than that in mild and moderate symptom patients [92.9％ (13/14) vs.62.5％ (10/16),66.7％(14/21)] (P ＜0.05).The rate of abnormal EGG in mild and moderate symptom patients had no significant difference (P ＞ 0.05).The rate of GE between Helicobacter pylori (Hp) positive patients and Hp negative patients had no significant difference (P ＞ 0.05).The rate of abnormal EGG in Hp positive patients was significantly higher than that in Hp negative patients [90.0％ (18/20) vs.61.3％ (19/31)] (P ＜ 0.05).The rate of GE and the rate of abnormal EGG had no significant difference between patients with and without active gastritis(P ＞ 0.05).Conclusions The abnormality of EGG plays an important role in the pathogenesis of FD.There is no significant relationship between EGG and GE.The patients with severe symptom and with Hp positive have higher abnormal EGG percentage.Gastritis has no significant correlation with EGG or GE.