The clinical investigation of application of nasal continuous positive airway pressure in neonatal respiratory distress syndrome after weaning from mechanical ventilation / 中国医师进修杂志

ABSTRACT

Objective To investigate the validity and clinical value of application of nasal continuous positive airway pressure (NCPAP) in neonatal respiratory distress syndrome (NRDS) after weaning from mechanical ventilation.Methods The 92 infants with NRDS received mechanical ventilation were randomly divided into the group of NCPAP (46 cases) and the group of oxygen via head box (46 cases) by systematic sampling method.The successful rate of weaning from mechanical ventilation,and incidence of complications such as apnea,broncho-pulmonary dysplasia,ventilator-associated pneumonia,intraventricular hemorrhage,periventricular leukomalacia,retinopathy of premature infant were compared between the 2 groups.Results The group of NCPAP,41 cases were successful of weaning from mechanical ventilation,the successful rate was 89.13％ (41/46).The group of oxygen via head box,33 cases were successful of weaning from mechanical ventilation,the successful rate was 71.74％(33/46).There was statistical difference between the 2 groups (P ＜0.05).The incidences of apnea and broncho-pulmonary dysplasia in the group of NCPAP were significantly lower than those in the group of oxygen via head box [15.22％ (7/46) vs.36.96％ (17/46),6.52％ (3/46) vs.21.74％ (10/46)],there were statistical differences between the 2 groups (P ＜ 0.05).There were no statistical differences in the incidences of ventilator-associated pneumonia,intraventricular hemorrhage,periventricular leukomalacia,retinopathy of premature infants between the 2 groups (P ＞ 0.05).Conclusion NCPAP is more effective than directly removing respirator in the infants with NRDS weaning from mechanical ventilation,it deserves further study and application in clinical practice.