Analysis of drug resistance in gram-negative bacteria in intensive care unit infection / 中华老年医学杂志

ABSTRACT

Objective To explore the gram-negative bacteria distribution and drug resistance in severe infections patients in ICU in our hospital.Methods Gram-negative bacteria in 260 cases of the clinical specimens from ICU department in our hospital from Mar 2012 to Mar 2013 were isolated and cultured,and the distribution and drug resistance in main gram-negative bacteria were analyzed.Results 300 cases of gram-negative bacteria were isolated from the 260 cases of specimens,and 203 cases were isolated from sputum,accounting for 67.7％.The mainly gram-negative bacteria in 300 cases were as followsPseudomonas aeruginosa (53 cases),Acinetobacter baumannii (45 cases),Klebsiella pneumonia (39 cases),Escherichia coli (33 cases) and Enterobacter cloacae (29 cases).The resistance rates of Pseudomonas aeruginosa to ampicillin/sulbactam and ceftriaxone were 73.6 ％ and 66.0％,Acinetobacter baumannii to ampicillin/sulbactam and piperacillin/tazobactam were 80％ and 68.9％,Klebsiella pneumoniae to ampicillin/sulbactam and ciprofloxacin were 53.8％ and 48.7％,Escherichia coli to levofloxacin and ampicillin/sulbactam were 78.8％ and 75.8％,Enterobacter cloacae to ampicillin/sulbactam and ceftriaxone were 82.8％ and 65.5 ％,respectively.Conclusions Drug resistance in gram-negative bacteria in ICU infection is more severe,and more attention should be paid to sterilization in ICU ward and rational use of antibiotics in order to minimize the risk of infection.