Role of histone acetylation in diabetes mellitus / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism
;
(12): 167-170, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-443381
ABSTRACT
Histone acetylation is a crucial part of histone modifications in epigenetics.Histone acetylation is involved in the onset of diabetes and diabetic complications,through the mechanism of inducing hyperglycemia by means of metabolic memory effect,interfering islet development and regulating the expression of inflammatory factors and pathogenic genes.Genome-wide association studies are gradually unveilling the pathogenesis of diabetes and preclinical studies are rapidly elucidating that histone deacetylase should be considered as a new target for the treatment of diabetes.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Endocrinology and Metabolism
Ano de publicação:
2014
Tipo de documento:
Artigo
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