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Identification of Tumor Suppressor Genes on Chromosome 21 / 대한흉부외과학회지
The Korean Journal of Thoracic and Cardiovascular Surgery ; : 141-147, 2009.
Artigo em Coreano | WPRIM | ID: wpr-44393
ABSTRACT

BACKGROUND:

We performed this study to identify the tumor suppressor genes located in the long arm of chromosome 21 in non-small cell lung cancer. MATERIAL AND

METHOD:

The genes of USP25 in 21q11.2, NCAM2, ADAMTS1 in 21q21.2, and Claudin-8 (CLDN8), Claudin-17 (CLDN17) and TIAM1 in 21q22.1 were investigated for their gene expressions, genetic alterations and promoter methylation.

RESULT:

The expressions of CLDN8 and CLDN17 were significantly decreased in 7 (L132, H157, H358, H522, H1299, H1703 and HCC2108) of 13 cell lines, and the expression of ADAMTS1 was also significantly reduced in 6 cell lines (A549, SW900, H1299, H1373, H1703 and H1793). There were no genetic alterations by PCR-SSCP and cDNA cloning in the cell lines with a decreased gene. In the cell lines with a decreased gene expression, the mRNA expression was increased significantly with treatment of 5-Aza-CdR.

CONCLUSION:

These results suggest that the ADMTS1, CLDN8 and CLDN17 may act as tumor suppressor genes.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Braço / Cromossomos Humanos Par 21 / RNA Mensageiro / Expressão Gênica / Linhagem Celular / Genes Supressores de Tumor / Células Clonais / DNA Complementar / Carcinoma Pulmonar de Células não Pequenas / Clonagem de Organismos Tipo de estudo: Estudo diagnóstico Idioma: Coreano Revista: The Korean Journal of Thoracic and Cardiovascular Surgery Ano de publicação: 2009 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Braço / Cromossomos Humanos Par 21 / RNA Mensageiro / Expressão Gênica / Linhagem Celular / Genes Supressores de Tumor / Células Clonais / DNA Complementar / Carcinoma Pulmonar de Células não Pequenas / Clonagem de Organismos Tipo de estudo: Estudo diagnóstico Idioma: Coreano Revista: The Korean Journal of Thoracic and Cardiovascular Surgery Ano de publicação: 2009 Tipo de documento: Artigo