Chemokine receptor 4 and tumors / 国际肿瘤学杂志

ABSTRACT

Chemokine receptor 4 (CXCR4) belongs to G protein-coupled receptor superfamily.It can induce immune cells directed chemotaxis and keep their homeostasis.CXCR4 expresses on a variety of tissues and cells.In different tumors and at different stages of tumor,CXCR4 expression is significantly higher than that in normal tissue.CXCR4 plays an important role in tumor progression since it is involved in tumor cell proliferation,adhesion,invasion and metastasis.