The expression of RRM1,ERCC1 of non-small cell lung cancer and its prognosis of platinum-based chemotherapy / 重庆医学

ABSTRACT

Objective To examine the protein expression levels of ERCC1 and RRM1 in non-small cell lung cancer(NSCLC)and its adjacent tissues in order to identify the the relationship between these expression profiles ,the pathological features and survival time of NSCLC undergoing platinum-containing chemotherapy .Methods The levels of ERCC1 and RRM1 protein expression in 121 NSCLC and adjacent cancer tissue were measured by immunohistochemistry .The relationship between survival time and the expres-sion of these two proteins was used by follow-up study .Results ERCC1 and RRM1 exhibited higher expression in NSCLC cancer compared with normal cancer tissues (P<0 .05) .After receiving platinum-containing chemotherapy postoperatively ,patients with ERCC1 or RRM1 negative expression showed prolonged median overall survival and median time to progression compared with those with positive expression (P<0 .05) .Conclusion The expression of ERCC1 ,RRM1 may have important correlation with the development of lung cancer .ERCC1 or RRM1 of negative protein expression has positive sensitive with platinum .