PI3K-Akt signaling pathway and chemotherapy drug resistance in cancer / 国际肿瘤学杂志

ABSTRACT

PI3K-Akt signaling pathway plays a critical role in the regulation of cell proliferation,differentiation and apoptosis,and is closely related to the physiological function of cells and thus may cause certain diseases.The excessive activation of this pathway is found closely associated with the formation of drug resistance of tumors.Recent studies in vitro indicate that the combined chemotherapy drugs with PI3K-Akt signaling pathway inhibitors,can significantly enhance the efficiency of chemotherapy drug and lower the value of IC50.Therefore,PI3K-Akt signaling pathway has become an important target to inhibit tumor cell growth and reverse tumor drug resistance.