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Effect of Puerarin on Expression of NF-κB in Rats with Acute Lung Injury Induced by Oleic Acid / 中国药师
China Pharmacist ; (12): 732-734, 2014.
Artigo em Chinês | WPRIM | ID: wpr-446020
ABSTRACT

Objective:

To observe the expression of nuclear factor-kappa B( NF-κB) in rats with acute lung injury ( ALI) caused by oleic acid ( OA) and investigate the protective effect of puerarin ( Pue) in ALI.

Methods:

Twenty-four rats were randomly divided into three groupsthe control group, OA group and Pue group. Morphological changes in lung tissues were observed under a light mi-croscope and the expression of NF-κB in lung tissues were examined.

Results:

Morphological changes in lung tissues showed that pul-monary inflammation was relieved in Pue group compared with that in OA group. Compared with the control group, the expression of NF-κB was increased obviously in OA group (0. 39 ± 0. 07 vs 0. 12 ± 0. 04, P<0. 05), and that was decreased obviously in Pue group (0. 24 ± 0. 05), which was still higher than that in the control group (P<0. 05).

Conclusion:

Puerarin can alleviate the inflammation reaction in ALI through inhibiting the expression of NF-κB.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: China Pharmacist Ano de publicação: 2014 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: China Pharmacist Ano de publicação: 2014 Tipo de documento: Artigo