Related risk factors for the severity of white-matter hyperintensity in stroke patients / 中国医师进修杂志

ABSTRACT

Objective To investigate the risk factors for the severity of white-matter hyperintensities (WMHs) in ischemic stroke patients.Methods Clinical and radiological data of acute ischemic stroke (AIS) patients were analyzed retrospectively.Results A total of 144 patients with AIS were enrolled including 89 cases of hypertension,32 eases of diabetes,43 cases of hyperlipidemia,21 cases of coronary heart disease,44 cases of atrial fibrillation; 60 cases of large artery atherosclerosis,8 cases of perforating artery disease,64 cases of cardiogenic stroke type,4 cases of other causes type and 8 cases of unexplained.U.S.national institutes of health stroke scale score was (6.06 ± 3.98) scores.WMHs score was (7.81 ± 4.93) scores,and median score was 6.5 scores.WMHs score 0-6 scores group had 72 cases,and 7-24 scores group had 72 cases.The age,systolic pressure,hyperhomocysteinemia(HHe) incidence in 0-6 scores group was statistically lower than that in 7-24 scores group [(61.08 ± 12.45) years vs.(72.03 ± 10.13) years,(149.40 ±25.43) mmHg (1 mmHg =0.133 kPa) vs.(159.19 ±23.63) mmHg,12.5％(9/72) vs.29.2％ (21/72)] (P ＜ 0.05).Logistic regression analysis showed that age and HHe was independent risk factor for the severity of WMHs in AIS patients (P ＜ 0.05).Conclusion Age and HHe is independent risk factor for the severity of WMHs in AIS patients.