Clinical analysis of irregular antibody detection before blood transfusion in 2 500 cases / 中国基层医药

ABSTRACT

Objective To investigate the clinical significance and application value of the irregular antibody test before transfusion.Methods The irregular antibody test was conducted in 2 500 patients before blood transfusion.Results Through the analysis of irregular antibody examination of 2 500 patients with blood transfusion,15 cases appeared irregular antibodies in the serum,the positive rate was 0.60％.The positive rate of male irregular antibody was 0.12％ (3/2 500),the positive rate of female irregular antibody was 0.48％ (12/2 500).The positive rate of female irregular antibody was significantly higher than that of male irregular antibody (x2 =7.34,P ＜ 0.05) ; The irregular antibodies were mainly anti C,anti D,anti E and anti M type and non-specific antibody,the proportions were 13.3％,26.7％,20.0％,33.3％,6.7％.The incidence rate of blood transfusion hypersensitivity reactions in irregular antibody positive donor was 100.0％,that in irregular antibody negative patients was 0.0％,the difference between the two groups was statistically significant (x2 =9.28,P ＜ 0.05).Conclusion Irregular antibody test in patients before blood transfusion can effectively guide the patients to correct blood transfusion,and can effectively prevent and reduce blood transfusion hypersensitivity,improve the safety in the process of blood transfusion.