Local radiotherapy for palliation in multiple myeloma patients with symptomatic bone lesions
Radiation Oncology Journal
; : 59-63, 2016.
Article
em En
| WPRIM
| ID: wpr-44794
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE: To evaluate the clinical outcomes of symptomatic bone lesions in patients with multiple myeloma (MM) who received local radiotherapy (LRT). MATERIALS AND METHODS: Fifty-one patients with 87 symptomatic bone lesions treated via LRT were analyzed. LRT was delivered at a median total dose of 21 Gy (range, 12 to 40 Gy) in a median of 7 fractions (range, 4 to 20 fractions). The clinical outcomes of LRT and the factors affecting treatment response were assessed. RESULTS: After a median follow-up time of 66.7 weeks, symptom relief was achieved for 85 of 87 lesions (97.7%). The median time to symptom relief was 7 days from the start of LRT (range, 1 to 67 days). The duration of in-field failure-free survival ranged from 1.1 to 450.9 weeks (median, 66.7 weeks). The radiation dose or use of previous and concurrent chemotherapy was not significantly associated with in-field failure for LRT (p = 0.354, 0.758, and 0.758, respectively). CONCLUSION: Symptomatic bone lesions in patients with MM can be successfully treated with LRT. A higher radiation dose or the use of concurrent chemotherapy may not influence the in-field disease control. A relatively low radiation dose could achieve remission of symptoms in patients with MM.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Cuidados Paliativos
/
Radioterapia
/
Seguimentos
/
Tratamento Farmacológico
/
Mieloma Múltiplo
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Radiation Oncology Journal
Ano de publicação:
2016
Tipo de documento:
Article