Expression and clinical significance of IL-23 and IL-17 in patients with colorectal cancer / 中国肿瘤临床
Chinese Journal of Clinical Oncology
;
(24): 580-584, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-448339
ABSTRACT
Objective:
This study was conducted to investigate the levels of IL-23 and IL-17 in sera and tumor tissues and to ana-lyze their association with clinico-pathological parameters in patients with colorectal cancer (CRC).Methods:
A total of 24 healthy sub-jects and 56 patients with CRC were recruited in this study. Enzyme-linked immunosorbent assay was performed to measure the concen-trations of IL-23 and IL-17 in the sera of CRC patients and healthy controls and in cultured normal tissues and tumor tissues from CRC patients.Results:
The levels of serum IL-23 and IL-17 were significantly higher in CRC patients than in healthy controls (P0.05). Tumor supernatant IL-17 level was correlated with tumor differentiation, lymph node metastasis, and TNM stage (P<0.05), whereas tumor supernatant IL-23 level was correlated only with TNM stage (P<0.05). Conclu-sionIL-23 and IL-17 may be involved in the immuno-pathogenesis of CRC progression.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Clinical Oncology
Ano de publicação:
2014
Tipo de documento:
Artigo
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