Effects of Shengqing Capsules on cholelithiasis-related genes in guinea pigs / 中西医结合学报
Journal of Integrative Medicine
;
(12): 207-10, 2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-449733
ABSTRACT
OBJECTIVE:
To explore the molecular mechanisms of Shengqing Capsules in treating cholelithiasis.METHODS:
Sixty female guinea pigs were randomized into 3 groups group I (fed with normal diet), group II (fed with low-protein diet) and group III (fed with low-protein diet and Shengqing Capsules). After six-week feeding, the gallstone formation and the expressions of bilirubin UDP-glucuronosyltransferase (B-UGT) mRNA and cholesterol 7alpha-hydroxylase (CYP7A1) mRNA were observed.RESULTS:
The proportions of stone-formed in groups I, II and III were 2/14, 9/12 and 4/14, respectively. There were significant differences among the three groups (P<0.05). The expressions of B-UGT and CYP7A1 mRNAs were higher in both group I and group III as compared with those in the group II (P<0.05).CONCLUSION:
Shengqing Capsules can reduce the rate of stone-formation, which may be due to its interference of metabolism of bilirubin and cholesterol and up-regulation of the expressions of B-UGT and CYP7A1 mRNAs.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Ensaio Clínico Controlado
Idioma:
Chinês
Revista:
Journal of Integrative Medicine
Ano de publicação:
2005
Tipo de documento:
Artigo
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