Significance of combined detection of tissue polypeptide antigen and human epididymal secretory protein 4 in the diagnosis and disease monitoring for ovarian epithelial cancer / 中国基层医药

ABSTRACT

Objective To study the clinical value of combined detection of tissue polypeptide antigen(TPA) and human epididymal secretory protein 4 (HE4) in the diagnosis and disease monitoring for ovarian epithelial cancer.Methods 82 cases with epithelial ovarian cancer were enrolled in ovarian cancer group,93 cases with benign ovarian lesions were selected as the benign ovarian lesions group,100 healthy people were selected as the control group.Serum TPA and HE4 were detected by ELISA.Results TPA-positive rates in the ovarian cancer group,benign ovarian lesions group and control group were 70.7％,8.6％ and 2.0％,respectively.The TPA-positive rate of ovarian cancer group was higher than benign ovarian lesions group and control group (x2 =33.69,82.95,all P ＜ 0.01).But the difference was not statistically significant between the benign ovarian lesions group and the control group(x2 =3.80,P ＞ 0.05).HE4 positive rates of the ovarian cancer group,benign ovarian lesions group and control group were 82.9％,11.8％,3.0％.The HE4 positive rate of ovarian cancer group was higher than benign ovarian lesions group and control group (x2 =36.72,78.33,all P ＜ 0.01).But the difference was not statistically significant between the benign ovarian lesions group and the control group(x2 =3.28,P ＞ 0.05).The sensitivity,specificity and accuracy of TPA in the diagnosis of ovarian cancer were 70.7 ％,95.2％,88.7％.The sensitivity,specificity and accuracy of HE4 in the diagnosis of ovarian cancer were 82.9 ％,97.2％,92.8％.Conclusion TPA and HE4 can improve the accuracy of the diagnosis of ovarian cancer.