Adverse effects of fetal growth restriction on development of fetal cerebral function / 中华围产医学杂志

ABSTRACT

Objective To determine the adverse effects of fetal growth restriction (FGR) on the development of fetal cerebral function.Methods Sixty small for gestational age (SGA) and 40 appropriate gestational age (AGA) infants with a gestational age ranging from 37 weeks to 40+6 weeks who were hospitalized in the Ba Yi Children's Hospital Affiliated to Beijing Military General Hospital were included in this study.Patients with fetal distress,birth asphyxia,hyperspasmia,intracranial hemorrhage,periventricular leukomalacia,intracranial infection,septicemia and congenital abnormalities were excluded from the study.Amplitude-integrated electroencephalography (aEEG) was used to monitor the baby's cerebral function within three days after birth.The monitoring time was two to four hours in each infant.The observational indices included continuity,sleep wake cycling (SWC),interburst interval (IBI),minimum voltage and maximum voltage.Student's t test,Chi-square test and analysis of variance were used to compare differences between the groups.Results Continuitythe frequency ofaEEG continuity in the SGA and AGA groups was 15.0％ (9/60) and 70.0％ (28/40),respectively (x2=31.14,P=0.00).SWCthe frequency of aEEG SWC in the SGA and AGA groups was 15.0％ (9/60) and 70.0％ (28/40) (x2=31.14,P-0.00).IBIthe frequency of IBI in the SGAandAGAgroups was (14.55±0.75) s and (5.09±0.89) s (t=57.21,P=0.00).Maximum voltagethe maximum voltage in the SGA and AGA groups was (10.40± 2.61) t V and (16.42± 5.53) μ V (t=-6.43,P=0.00).Minimum voltagethe minimum voltage in the SGA and AGA groups was (4.02± 1.61) μ V and (6.98±3.82) μV (t=4.63,P=0.00).Lower birth weight,hypoglycemia (without hypoglycemic encephalopathy) or hyperbilirubinemia (without bilirubin encephalopathy) had no significant influence on fetal cerebral function (all P＞0.05).Conclusions SGA infants have poor continuity,absence of SWC,longer IBI,and lower maximum and minimum voltage,which suggests that FGR,to an extent,has an adverse influence on the development of fetal cerebral function.