Frequency of Bone Marrow Toxicity by Using Pattern of Azathioprine in Inflammatory Bowel Disease Patients
Intestinal Research
;
: 244-250, 2012.
Artigo
em Coreano
| WPRIM
| ID: wpr-45087
ABSTRACT
BACKGROUND/AIMS:
The most important adverse effect of azathioprine (AZA) is bone marrow toxicity (BMT). Many physicians have preferred a gradual dose increment (GDI) policy for the prevention of BMT. The aim of this study was to evaluate the efficacy of GDI for the prevention of AZA-induced BMT in inflammatory bowel disease (IBD) patients.METHODS:
The medical records of IBD patients who received AZA in 6 university hospitals were reviewed. The patients were divided into two groups the GDI group (initial dose or =2 mg/kg).RESULTS:
A total of 308 patients were enrolled (male to female ratio, 12.3; mean age, 34.91+/-14.19 years; ulcerative colitis, 43.5%; Crohn's disease, 55.2%; and intermediate colitis, 1.3%). The overall incidence of BMT was 16.2% (50/308). BMT developed most frequently between fourth to eighth week (26%, 13/50). The rate of BMT of the non-GDI group was significantly higher than that of the GDI group (27.5%, 11/40 vs. 14.6%, 39/268, P=0.038). A multivariate analysis showed that the only factor related to BMT was a non-GDI policy (P=0.036; odds ratio, 2.41; 95% confidence interval, 1.06-5.49).CONCLUSIONS:
A GDI policy could be useful for reducing AZA-induced BMT in Korean IBD patients.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Azatioprina
/
Medula Óssea
/
Doenças Inflamatórias Intestinais
/
Colite Ulcerativa
/
Doença de Crohn
/
Razão de Chances
/
Prontuários Médicos
/
Incidência
/
Análise Multivariada
/
Colite
Tipo de estudo:
Estudo de etiologia
/
Estudo de incidência
/
Estudo prognóstico
Limite:
Feminino
/
Humanos
Idioma:
Coreano
Revista:
Intestinal Research
Ano de publicação:
2012
Tipo de documento:
Artigo
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