Effect of mild hypothermia on recovery from cisatracurium blockade during recovery from anesthesia / 中华麻醉学杂志

ABSTRACT

Objective To evaluate the effect of mild hypothermia on the recovery from cisatracurium blockade during the recovery from anesthesia in patients .Methods Thirty ASA physical status Ⅰ or Ⅱ patients , aged 18-64 yr , with body mass index 18-25 kg/m2 , scheduled for elective abdominal surgery under general anesthesia ,were enrolled in the study .The patients were divided into 2 groups according to the body temperature recorded when cisatracurium infusion was stopped at the end of surgery .The body temperature 36.0-36.9 ℃served as normothermia group (group N , n=14 ) and 34.0-35.9 ℃ served as mild hypothermia group (group H , n= 16 ) . The body temperature was measured by a thermocouple placed in the nasopharynx . Neuromuscular function was monitored by measuring the evoked mechanical response of the adductor pollicis muscle to supramaximal train-of-four (TOF) stimulation (frequency 2 Hz ,wave length 0.2 ms ,intensity 50 mA ,interval 15 s) of the ulnar nerve at the wrist using TOF-Watch SX? .Cisatracurium was intravenously infused at 1-3μg·kg-1 ·min-1 during surgery to maintain neuromuscular block with 1% surgery .The recovery index (time for T1 to recover from 25% to 75% ) ,time for T1 to recover from 10% to 75% ,and time for T1 to recover from 10% to T4/T1 ratio of 0.9 were recorded . Results Compared with group N ,the recovery index ,time for T1 to recover from 10% to 75% ,and time for T1 to recover from 10% to T4/T1 ratio of 0.9 were significantly prolonged in group H ( P<0.05) .Conclusion Mild hypothermia can inhibit the recovery from cisatracurium blockade during the recovery from anesthesia in patients .