Protective effect of dexmedetomidine on mechanically ventilated patients with pulmonary contusion / 中国中西医结合急救杂志

ABSTRACT

Objective To approach the protective effect of dexmedetomidine on mechanically ventilated patients with pulmonary contusion. Methods A prospective randomly controlled trial was conducted. 70 mechanically ventilated patients with pulmonary contusion from January 2010 to December 2012 in the Critical Care Medicine of Foshan Hospital of Traditional Chinese Medicine were divided into a control group and a therapy group by the difference in number odd or even,with 35 patients in each group. Based on the same principles of comprehensive treatment,the control group used midazolam,and the therapy group used dexmedetomidine for sedation. The measured parameters included oxygenation index(PaO2/FiO2),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6), and extra-vacular lung water index(EVLWI)for both groups on the1st and 5th day. The incidence of delirium,the time of mechanical ventilation,and the incidence of hypotension were observed in both groups. Results Compared with those on the 1st day,TNF-α,IL-6 and EVLWI on the 5th day were decreased significantly in both groups〔the control group TNF-α(ng/L)1.29±0.38 vs. 2.21±0.37,IL-6(ng/L)97.97±28.77 vs. 131.03±41.52,EVLWI (mL/kg)8.25±2.03 vs. 11.96±3.36;the therapy group TNF-α1.06±0.33 vs. 2.32±0.37,IL-682.07±23.35 vs. 134.98±64.25, EVLWI(mL/kg)6.74±1.33 vs. 11.23±2.78, all P0.05). Conclusion Dexmedetomidine has protective effect on mechanically ventilated patients with pulmonary contusion, and it is an relatively ideal sedative drug for these patients.