The relationship between vitamin D levels and lung function of patients with bronchial asthma / 中国综合临床

ABSTRACT

Objective To investigate the relationship between serum 25- hydroxyvitamin D(25(OH) D3)level and lung function of bronchial asthma patients. Methods Thirty-nine bronchial asthma patients with severe,moderate,mild stage(each for 13 cases)in respiratory department of the First People's Hospital of Jining from Jan. to Oct. 2013 were selected as our subjects. Fifth healthy people were selected as control group. Serum 25(OH)D3 and pulmonary function indexes were detected,and the percentage of forced expiratory volume in one second(FEV)in predicted value(FEV1% pred)was calculated. Results The FEV1% pred of patients with mild,moderate and severe stage bronchial asthma were(86. 62 ± 10. 80)% ,(67. 23 ± 11. 30)% and(31. 26 ± 12. 80)% pespectively,and there were significant between groups(P < 0. 01). The level of 25(OH)D3 in patients with mild,moderate and severe bronchial asthma were(14. 33 ± 6. 82),(10. 28 ± 5. 51),(5. 68 ± 3. 26)μg/ L respectively,lower than that in control group((17. 28 ± 7. 12)μg/ L),and the differences were statistically significant(P < 0. 01 or 0. 05). There was a positive correlation between serum 25(OH)D3 and pulmonary function,and the linear regression equation wasy = - 0. 0115 + 0. 167x. Conclusion The deficiency of Vitamin D relate to the occrrence and degreed of bronchial asthmaisease,and suppliment of vitamin D should also be used as a therapy in patients with bronchial asthma.