Progress in experimentaI research on aIIergic asthma treatment with triptoIide / 中国药理学与毒理学杂志

ABSTRACT

Triptolide(TP)is a diterpenoid epoxide purified from a Chinese herb Tripterygiumwilfordii Hook. f.. lt has been shown to have multiple pharmacological activities,such as anti-tumor,anti-inflammatory,immune-suppressive effects. TP can reduce airway hyperresponsiveness,decrease the proliferation of airway smooth muscle,and produce potential therapeutic effect in airway remodeling. The effect of TP on allergic asthma may be related to its inhibition of maturation of dendritic cells,rebalance of the function of Th1 and Th2,reduction of the secretion of inflammatory factors,and decrease of the infiltration of eosinophils.