The Protective Roll of Rosuvastatin on Chronic Heart Failure in Rats With its Effect on Asymmetric Dimethylarginine Metabolic Pathway / 中国循环杂志
Chinese Circulation Journal
; (12): 743-747, 2014.
Article
em Zh
| WPRIM
| ID: wpr-453957
Biblioteca responsável:
WPRO
ABSTRACT
Objective: To investigate the protection roll of rosuvastatin on chronic heart failure (CHF) in rats with its effect on asymmetric dimethylarginine (ADMA) metabolic pathway. Methods: A total of 36 male SD rats were randomly divided into 3 groups, n=12 in each group. Isoproterenol (ISO) group, the rats received ISO subcutaneous injection (5mg·kg·d) for 7 days to establish CHF model, and then received normal saline gavage administration for 7 days. Rosuvastatin (ROS) treatment group, the rats received ISO with ROS for 7 days, then continuously receiving ROS until 14 days. Normal control group, the rats received saline gavage administration for 7 days. The related serum index and haemodynamic parameters were examined, myocardial pathological changes were observed and the relevant protein expression was measured by Western blot analysis. Results: Compared with Normal control group, ISO group had obviously increased troponin (cTn I), serum ADMA,-LVdP/dtmin, all P0.05. Conclusion: Rosuvastatin has the protective roll on ISO induced CHF in rats, which might be related to decreased serum levels of cTn I, BNP and ADMA metabolic pathway regulation.
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Índice:
WPRIM
Idioma:
Zh
Revista:
Chinese Circulation Journal
Ano de publicação:
2014
Tipo de documento:
Article