Changes in Fingerprint Pattern of Compound Granatum Berberine Capsules before and after Irradiation / 中国药师
China Pharmacist
;
(12): 1480-1483, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-454396
ABSTRACT
Objective:
To investigate the component changes in compound granatum berberine capsules after the radioactive ray ir-radiation sterilization.Methods:
The chromatographic fingerprints were obtained on a Diamonsil C18 analytical column ( 250 mm × 4. 6 mm,0. 5 μm) with solvent system composed of acetonitrile-0. 033 mol·L-1 potassium dihydrogen phosphate, the flow rate was 1. 0 ml·min-1 and the detection wavelength was set at 265nm, the column temperature was maintained at 30℃, and the injection vol-ume was 10 μl.Results:
Totally 10 co-possessing peaks were selected as the fingerprint peaks for compound granatum berberine cap-sules, and the fingerprints exhibited promising separation for each peak and revealed the fingerprint information according to the techni-cal requirements of fingerprints for Chinese traditional medicines. Most components were with different degrees of reduction, and some peaks even lost after the irradiation.Conclusion:
The main ingredients show no statistically significant change after irradiation ( P>0. 05), suggesting the sterilization method is suitable for the preparation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Pharmacist
Ano de publicação:
2014
Tipo de documento:
Artigo
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