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Periostin in Mature Stage Localized Scleroderma
Annals of Dermatology ; : 268-275, 2017.
Artigo em Inglês | WPRIM | ID: wpr-45444
ABSTRACT

BACKGROUND:

Periostin is a novel matricellular protein expressed in many tissues, including bone, periodontal ligament, and skin. Although its expression is prominent in various fibrotic conditions, studies of periostin in localized scleroderma are rare.

OBJECTIVE:

To investigate the expression of periostin and other molecules in localized scleroderma.

METHODS:

A retrospective study of 14 patients with confirmed mature stage localized scleroderma was undertaken. Fourteen age-matched and biopsy site-matched subjects with normal skin were included as controls. Collagen fiber deposition, periostin, procollagen, transforming growth factor-β, and matrix metalloproteinase (MMP)-1 expression were assessed and compared between the two groups. Co-localization of α-smooth muscle actin and periostin was evaluated using confocal microscopy.

RESULTS:

Periostin was predominantly expressed along the dermo-epidermal junction in the controls. Conversely, patients with localized scleroderma demonstrated increased collagen fiber deposition and periostin expression that was more widely distributed along the entire dermis. MMP-1 staining showed increased expression in the epidermis and dermis of patients compared to scanty expression in the controls. A semi-quantitative evaluation showed a higher proportion of excessive collagen bundle deposition (57.1% vs. 7.1%, p=0.013), diffuse periostin positivity (42.9% vs. 0%, p=0.016), and moderate MMP-1 positivity (71.4% vs. 7.1%, p=0.001) in patients than in the controls.

CONCLUSION:

Compared to the controls, patients with localized scleroderma had enhanced periostin expression corresponding to increased collagen fiber deposition and unexpected overexpression of MMP-1. The results of this human in vivo study may implicate the pathogenesis of localized scleroderma.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Ligamento Periodontal / Esclerodermia Localizada / Esclerose / Pele / Biópsia / Estudos Retrospectivos / Actinas / Colágeno / Pró-Colágeno / Microscopia Confocal Tipo de estudo: Estudo observacional Limite: Humanos Idioma: Inglês Revista: Annals of Dermatology Ano de publicação: 2017 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Ligamento Periodontal / Esclerodermia Localizada / Esclerose / Pele / Biópsia / Estudos Retrospectivos / Actinas / Colágeno / Pró-Colágeno / Microscopia Confocal Tipo de estudo: Estudo observacional Limite: Humanos Idioma: Inglês Revista: Annals of Dermatology Ano de publicação: 2017 Tipo de documento: Artigo