The apolipoprotein E genotyping using the PCR-RFLP was useful to linkage analysis of Alzheimer's disease families
Experimental & Molecular Medicine
;
: 161-164, 1997.
Artigo
em Inglês
| WPRIM
| ID: wpr-45505
ABSTRACT
Apolipoprotein E (ape E) has three common alleles (ape epsilon 2, epsilon 3 and epsilon 4) that code for three major isoforms E2, E3 and E4. The isoforms differ from each other by a single amino acid substitutions at two positions and also differ in their binding affinity for the apo E receptors. Moreover, recently a strong association between the apo epsilon 4 allele and late-onset Alzheimer disease (AD) was demonstrated. In this study, were analyzed the apo E genotypes using the Hhal digestion of PCR amplified samples, and the apo epsilon 4 allele frequency from 70 AD patients and 106 normal population in Korea. The results suggested that the frequency of epsilon 4 allele among the AD patients (35.7%) was 3 times higher than that among the control population (13.7%). The data, which are in agreement with recent reports, suggests that the apo epsilon 4 allele is associated with AD in Korea.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Apolipoproteínas
/
Apolipoproteínas E
/
Reação em Cadeia da Polimerase
/
Substituição de Aminoácidos
/
Isoformas de Proteínas
/
Proteína-1 Relacionada a Receptor de Lipoproteína de Baixa Densidade
/
Digestão
/
Alelos
/
Doença de Alzheimer
/
Frequência do Gene
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Experimental & Molecular Medicine
Ano de publicação:
1997
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS