Correlation between acid-suppressive medications and risk of osteoporosis-related fractures:a meta-analysis / 中国组织工程研究
Chinese Journal of Tissue Engineering Research
;
(53): 5402-5406, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-455987
ABSTRACT
BACKGROUND:
Whether a long-term use of acid-suppressive medication for over 3 years can increase the risk of fractures, remains controversial.OBJECTIVE:
To systematical y review the effect of acid-suppressive medication on fracture risk.METHODS:
Clinical trials about the relationship of acid-suppressive medication use and risk of osteoporosis-related fractures were searched in MEDLINE, Cochrane Library, EMbase, and CNKI database. We also manual y searched some published and unpublished references. Study selection and assessment, data col ection and analyses were undertaken by two reviewers independently. The Cochrane Col aboration’s RevMan 5.0 software was used for data analyses. RESULTS ANDCONCLUSION:
After a comprehensive search, 11 original clinical trials were included in this meta-analysis, including 3 nested case-control studies, 5 case-control studies, and 3 cohort studies. Patients with fractures were more likely than controls to have previously received supply of proton pump inhibitors [odds ratio (OR)=1.29, 95%confidence interval (CI) (1.18-1.41), P<0.001]. The meta-analysis did not find a significant difference in the patients who received H2 receptor antagonists [OR=1.10, 95%CI (0.99-1.23), P=0.34]. A long-term use of proton pump inhibitors is associated with an increased risk of fracture in elderly persons already at a risk for osteoporosis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo de etiologia
/
Guia de Prática Clínica
/
Estudo observacional
/
Fatores de risco
/
Revisões Sistemáticas Avaliadas
Idioma:
Chinês
Revista:
Chinese Journal of Tissue Engineering Research
Ano de publicação:
2014
Tipo de documento:
Artigo
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