Simultaneous Determination of Palmatine, Berberine and Jateorhizine in Jinji Capsules by QAMS / 中国药师

ABSTRACT

Objective: To establish a quantitative analysis of multi-components by single marker ( QAMS ) for determining the three alkaloids in Jinji capsules. Methods:With the typical composition palmatine as the internal standard, the relative correction fac-tor ( RCF) between the palmatine and berberine or jateorhizine was respectively established, and the content of berberine and jateorhiz-ine was respectively calculated by QAMS. An external standard method was used to determine the three alkaloids, and the calculated values were compared with the estimated values by Pearson correlation coefficient. Results:There was no significant difference between the calculated values in QAMS and the estimated values in the external standard method, and the RCF was credible. Conclusion:The new method is feasible and accurate to evaluate the contents of the three alkaloids in Jinji capsules.