Therapeutic effect of oral racemic ibuprofen on patent ductus arteriosus in neonates / 心血管康复医学杂志

ABSTRACT

Objective:To explore the therapeutic effect and safety of oral ibuprofen (INN)on patent ductus arterio-sus (PDA)in neonates.Methods:A total of 160 neonates,who hospitalized in our hospital and were diagnosed as PDA by color echocardiography from Feb 2011 to Dec 2013,were enrolled.According to number table method, they were randomly and equally divided into high dose group (received INN 10mg/kg on the first day,then 5mg/kg on the second and third day)and low dose group (received INN 5mg/kg for 3d).PDA closure was observed,com-pared and analyzed between two groups after INN therapy.Results:After INN therapy,PDA closed in 57 cases (71.3%)in high dose group,it was significantly higher than that of low dose group (48.8%,39/80),P 0.05 all).Con-clusionHigh-dose ibuprofen possesses better therapeutic effect on patent ductus arteriosus in neonates;its adverse reactions are few;which can avoid postoperative pain in partial children.