Effects of Citicoline Acupoint Injection on Expression of Growth Associated Protein-43 in Rats with Traumatic Brain Injury / 中国康复理论与实践
Chinese Journal of Rehabilitation Theory and Practice
; (12): 835-838, 2014.
Article
em Zh
| WPRIM
| ID: wpr-456668
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WPRO
ABSTRACT
Objective To investigate the effects of injection of citicoline into Zusanli (ST36) acupoint on neural function and expression of growth associated protein-43 (GAP-43) in rats with traumatic brain injury. Methods 40 healthy adult male Sprague-Dawley rats were ran-domly divided into 5 groups:sham-operated group (group A, n=8), acupoint injection of citicoline group (group B, n=8), acupoint injection of saline group (group C, n=8), intraperitoneal injection of citicoline group (group D, n=8) and intraperitoneal injection of saline group (group E, n=8). Opened brain trauma was induced with the modified Feeney method in the groups B, C, D and E, and were treated as de-sign, once a day for 14 days. They were assessed with nervous function score and open-field test before and 8, 14, 15, and 22 days after inju-ry. The expression of GAP-43 in the brain were detected with immunohistochemistry 28 days after injury. Results The nervous function scores and open-field test scores improved more significantly in the group B than in the groups C, D and E (P<0.05). The expression of GAP-43 increased in the group B than in the groups C, D and E (P<0.05). Conclusion Acupoint injection of citicoline into Zusanli may im-prove the expressions of GAP-43 to promote the recovery of neural function in rats after traumatic brain injury.
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WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Rehabilitation Theory and Practice
Ano de publicação:
2014
Tipo de documento:
Article