Effect of metformin on SFRP5 release and insulin resistance in diabetic rat / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism
;
(12): 614-616, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-457109
ABSTRACT
Diabetic rat model accompanied by insulin resistance was established by intraperitoneal injection of streptozocin.Following metformin treatment for 5 weeks,ELISA was used to detect the level of plasma secreted frizzled-related protein (SFRP) 5,and immunohistochemistry was used to detect the expression of p-JNK in the liver.insulin resistance(IR) and p-JNK were significantly increased in diabetic group compared with the control group (P<0.05),while plasma SFRP5 level was reduced (P<0.01).After metformin treatment,the plasma SFRP5 levels were significantly increased (P<0.05),while IR and p-JNK was decreased (P<O.05).Metformin may ameliorate insulin resistance via upregulating the SFRP5 expression of diabetic rats.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Endocrinology and Metabolism
Ano de publicação:
2014
Tipo de documento:
Artigo
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