Syhthesis and antitumor activity of alkoxylbiphenyl/curcumine conjugates / 国际药学研究杂志
Journal of International Pharmaceutical Research
;
(6): 680-685, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-457399
ABSTRACT
Objecti ve To design and synthesize conjugates of alkoxylbiphenyl/C5-curcumine with antitumor activities. Methods Bicyclol,acetone and benzaldehyde with various substituents were used as raw materials. The target compounds were obtained by oxidizing and Aldol condensation reaction. And their antitumor activities were evaluated by MTS assay in the parental sensitive K562 and drug-resistant K562/A02 cell lines. Results Twelve alkoxylbiphenyl/C5-curcumine conjugates were prepared. Conclusion The synthetic procedure of the target compounds is simple,and the yield is high. Compound 3b could significantly inhibit K562 and drug-resistant K562/A02 cell proliferation,and the IC50 is 5.38 and 3.60μmol/L,respectively.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of International Pharmaceutical Research
Ano de publicação:
2014
Tipo de documento:
Artigo
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