Higher Plasma Thrombospondin-1 Levels in Patients With Coronary Artery Disease and Diabetes Mellitus
Korean Circulation Journal
;
: 100-106, 2012.
Artigo
em Inglês
| WPRIM
| ID: wpr-45787
ABSTRACT
BACKGROUND AND OBJECTIVES:
Thrombospondin-1 (TSP-1) is associated with atherosclerosis in animals with diabetes mellitus (DM). But, no study has investigated the role of TSP-1 in human atherosclerosis. This study investigated the relationship among plasma TSP-1 concentration, DM, and coronary artery disease (CAD). SUBJECTS ANDMETHODS:
The study involved 374 consecutive subjects with suspected CAD, who had undergone coronary angiography to evaluate effort angina. Patients were divided into four groups as follows DM(-) and CAD(-), DM(-) and CAD(+), DM(+) and CAD(-), and DM (+) and CAD(+).RESULTS:
We found that plasma TSP-1 levels were higher in patients with DM(+) and CAD(+) (n=103) than those in other patients (n=271) (p<0.01). A multivariate analysis showed that male gender {odds ratio (OR), 2.728; 95% confidence interval (CI), 1.035-7.187}, high density lipoprotein-cholesterol (OR, 0.925; 95% CI, 0.874-0.980), glycated hemoglobin (OR, 1.373; 95% CI, 1.037-1.817), and plasma TSP-1 (OR, 1.004; 95% CI, 1.000-1.008) levels were independently associated with the presence of CAD in patients with DM.CONCLUSION:
Plasma TSP-1 levels were higher in patients with DM(+) and CAD(+) than those in other patients, and plasma TSP-1 levels were independently associated with the presence of CAD in patients with DM. These findings show a possible link between human plasma TSP-1 concentration and CAD in patients with DM.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Plasma
/
Doença da Artéria Coronariana
/
Hemoglobinas
/
Carbonatos
/
Análise Multivariada
/
Angiografia Coronária
/
Vasos Coronários
/
Trombospondina 1
/
Diabetes Mellitus
/
Aterosclerose
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Korean Circulation Journal
Ano de publicação:
2012
Tipo de documento:
Artigo
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