AMPK/mTOR pathway and leucine resistance in sepsis / 医学研究生学报

ABSTRACT

Sepsis leads to inhibition of protein synthesis , known as leucine resistance .mTOR regulates protein synthesis by phosphorylation of S6K1 and 4E-BP1.AMPK is an important negative regulator of mTOR and its activity is in an abnormal state in sep-sis.This review briefly discusses the AMPK/mTOR pathway in Sepsis-induced leucine resistance .