Determination of Imatinib Mesylate Liposome and Related Substances by HPLC / 医药导报
Herald of Medicine
;
(12): 1496-1498, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-458212
ABSTRACT
Objective To establish a method for determination of imatinib mesylate liposome and related substances. Methods The liquid chromatography was carried out on a Kromasil C18 column. The mobile phase A consisted of methanol-octane sulfonate solution(4258). The mobile phase B consisted of methanol-octane sulfonate solution(496). The flow rate of gradient elution was 1. 2 mL·min-1 . The detection wavelength was 268 nm. The column temperature was room temperature. Results The intermediates and degraded substances could be seperated under the selected chromatographic conditions. Imatinib mesylate showed a good linear relationship within 1-100μg·mL-1,r=0. 999 1(n=5). Conclusion The method is specific, accurate,sensitive,and simple,and can be used for quality control of imatinib mesylate liposome.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Herald of Medicine
Ano de publicação:
2014
Tipo de documento:
Artigo
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