Effect of detecting moyamoya disease with ultrasonography on hemodynamics of extracranial internal carotid artery / 中国脑血管病杂志

ABSTRACT

Objective Toinvestigatetheeffectofwhetherposteriorcommunicatingartery(PCoA) patent or not on hemodynamics of extracranial internal carotid artery (EICA)in patients with moyamoya disease.Methods Atotalof103consecutivepatientswithmoyamoyadisease(unilaterallesion) detected by transcranial color Doppler ultrasonography (TCD)and Color Doppler flow imagining (CDFI), and confirmed by digital subtraction angiography (DSA)from August 2008 to April 2014 were enrolled. According to the patency of PCoA showed by DSA,the patients were divided into either a PCoA non-patent group (n=83)and a PCoA patent group (n=20). Eighty healthy subjects screened by TCD and CDFI in the same period were used as a control group. CDFI and TCD were used to detect the peak systolic velocity (PSV),end diastolic velocity (EDV),vascular resistance index (RI)and/or pulsatility index (PI)of EICA,and posterior cerebral artery (PCA)in subjects of both groups. Results (1 )There were significant differences in PSV,EDV and RI among the three groups (F=5. 76,12. 24,and 8. 10,respectively;all P<0. 05). The PSV of vascular EICA (42 ± 15 cm/s)and EDV (14 ± 7 cm/s)on the lesion sites in patients of the PCoA non-patent group were all lower than those in the control group (92 ± 24 and 38 ± 11 cm/s). The differences were statistically significant (all P<0. 05). The PSV of vascular EICA on the lesion sites in patients of the PCoA patent group was lower than that of the control group (P<0. 05),but EDV was higher than the control group (P<0. 05). (2)Compared with the control group,the RI value was increased in the PCoA non-patent group (P<0. 01)and that was decreased in the PCoA patent group (P<0. 01). (3)PSV and EDV of PCA in the moyamoya disease group were higher than those of the control group (P<0.05),andthePIvaluewaslowerthanthatofthecontrolgroup(P<0.01).Conclusion Whether PCoA patent or not in patients with moyamoya disease have different influences on hemodynamic parameters of EICA. PSV and EDV of the patients with PCoA non-patent are lower than those of the healthy subjects and their RI values are increased. EICA of the patent group is lower than PSV and RI of the control group, and their EDV is increased.