Vitreous Vascular Endothelial Growth Factor Concentration In Various Vitreoretinal Disorders
Journal of the Korean Ophthalmological Society
;
: 96-103, 2002.
Artigo
em Coreano
| WPRIM
| ID: wpr-45853
ABSTRACT
PURPOSE:
Vascular endothelial growth factor (VEGF) has been identified as an endothelial cell-specific angiogenic factor of intraocular neovascularization, a pathologic complication of many vitreoretinal disorders. We studied to evaluate clinical correlation of intravitreal VEGF concentration and various vitreoretinal disorders.METHODS:
Forty eight vitreous fluid samples were obtained at the time of vitreoretinal surgery from 43 patients of various disorders. Concentrations of VEGF1 6 5 in vitreous fluid were determined by Human VEGF ELISA kit and its correlation with diabetes, intraocular hemorrhage, neovascularization, proliferative vitreoretinopathy, retinal detachment, pan retinal photocoagulation, and postoperative condition was statistically analyzed.RESULTS:
Intravitreal concentrations of VEGF in case of intraocular hemorrhage (0.809+/-1.467 ng/ml), neovascularization (1.167+/-1.656 ng/ml), and anterior segment neovascularization (2.381+/-2.043 ng/ml) were significantly high (P<0.05).CONCLUSIONS:
VEGF plays a major role in the development of neovascularization in the various retinal disorders.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Retinaldeído
/
Descolamento Retiniano
/
Ensaio de Imunoadsorção Enzimática
/
Vitreorretinopatia Proliferativa
/
Fator A de Crescimento do Endotélio Vascular
/
Indutores da Angiogênese
/
Cirurgia Vitreorretiniana
/
Hemorragia
/
Fotocoagulação
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Coreano
Revista:
Journal of the Korean Ophthalmological Society
Ano de publicação:
2002
Tipo de documento:
Artigo
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