Analysis of Heart Rate Variability and Arrhythmia in Patients With Resistant Hypertension / 中国循环杂志

ABSTRACT

Objective: To explore heart rate variability (HRV) and arrhythmia in patients with resistant hypertension. Methods: Our work included 3 groupsResistant hypertension (RH) group, n=39, Non-resistant hypertension (NRH) group, the hypertension could be controlled by 1-3 medications, n=42 and Control group, composed of 40 healthy subjects. The 24h ambulatory blood pressure and electrocardiogram were monitored, the time-domain of HRV and arrhythmia parameters were compared among 3 groups which including standard deviation of all normal RR intervals (SDNN), standard deviation of the average normal RR intervals for all 5-min segments (SDANN), the mean of standard deviation of all 5-minute RR intervals (SDNN Index), the root mean square of the differences between adjacent R-R intervals (rMSSD) and the percentage of adjacent R-R intervals varied by more than 50 ms (pNN50). Results: Compared with Control group, both RH and NRH groups showed decreased time-domain HRV parameters, all P0.05. Conclusion: RH patients had decreased HRV and increased arrhythmia, especially with the higher incidence of atrial arrhythmia.