Redox Regulation of Cardiac Na and Ca Handling Protein / 天津医药
Tianjin Medical Journal
; (12): 1043-1047, 2014.
Article
em Zh
| WPRIM
| ID: wpr-458974
Biblioteca responsável:
WPRO
ABSTRACT
Cardiac contractile dysfunction and arrhythmic genesis are resulted from disturbed intracellular Na+and Ca2+ handling under condition of oxidation stress. Stress-induced intracellular signaling regulated mechanisms in which many activated stress kinases, such as cAMP-dependent protein kinase A, protein kinase C , Ca/calmodulin-dependent pro-tein kinaseⅡand classical pathways, are known to be involved. However, it is becoming increasingly evident that reactive oxygen species may directly oxidize these kinases, Na+and Ca2+channel protein and transporters, which lead to changing of intracellular Na+and Ca2+accumulation, and to trigger of arrhythmias.
Texto completo:
1
Índice:
WPRIM
Idioma:
Zh
Revista:
Tianjin Medical Journal
Ano de publicação:
2014
Tipo de documento:
Article