The application value of HLA-B27 detection in the diagnosis of spondyloarthritis / 国际检验医学杂志

ABSTRACT

Objective To analyze human leucocyte antigen B27(HLA-B27) diagnostic value in spondyloarthritis(SpA) .Methods Using flow cytometry to detect HLA-B27 expressions of 298 SpA patients(SpA group) and 195 non-SpA patients(non-SpA group) .Results 227 patients were positive in the 493 patients .In SpA group ,the positive rates of HLA-B27 expressing in ankylo-sing spondylitis (AS ) ,juvenile spondyloarthritis (JSpA ) ,reactive arthritis (ReA ) ,undifferentiated spondyloarthritis (USpA ) , psoriatic arthritis(PsA) were 87 .66% ,59 .09% ,58 .33% ,37 .18% ,25 .00% ,respectively .In non-SpA group ,the positive rates of HLA-B27 expressing in rheumatoid arthritis ,rheumatic arthritis ,cervical or lumbar disease ,osteoarthritis ,gouty arthritis were 18 . 18% ,17 .86% ,16 .67% ,11 .76% ,0 .00% ,respectively .The SpA group and the non-SpA group of HLA-B27 positive comparative differences was statistically significant(P<0 .01) .Conclusion The HLA-B27 is correlated with SpA ,and can provide reference for clinical diagnosis of SpA especially the AS .