The research progress on double-hit lymphoma / 中国癌症杂志

ABSTRACT

Recently, double-hit lymphoma (DHL) was clarified to be a molecular category of B-cell lym-phoma, which was mainly related to MYC and Bcl-2 genes translocation. Fluorescence in situ hybridization (FISH) is the gold standard of diagnosis and it is controversial to detect the expression of MYC and Bcl-2 protein by immuno-histochemistry. DHL, which was found to be aggressive according to many retrospective analyses, mainly develops in patients with diffuse large B-cell lymphoma and grey zone lymphoma. Both rituximab combination and transplant consolidation were not able to signiifcantly overcome the poor prognosis of DHL. Novel and speciifc molecular targeted agents need to be explored and investigated in order to improve the treatment outcome.