The effects of DPPI on LPS-induced periodontitis in mice / 实用口腔医学杂志

ABSTRACT

Objective:To study the effect of dipeptidyl peptidase I(DPPI)on the damage of alveolar bone and inflammatory re-sponse of periodontium in periodontitis mice.Methods:Periodontitis model of left first molars was established in 1 0 DPPI-/-mice and 1 0 wild type(WT)mice by E.coli LPS injection and the right ones were served as the control by PBS injection.Micro-CT scanning and HE staining were performed to compare the damage of alveolar bone and inflammatory response of periodontium between the 2 groups.Results:The decreace of alveolar bone height in DPPI-/-mice was less than that in WT mice〔(Maxillary(0.001 7 ± 0.000 4)mm vs (0.202 0 ±0.008 6)mm;Mandibular(0.034 2 ±0.002 9)mm vs (0.332 8 ±0.01 2 5)mm〕(P<0.05).HE staining showed that the inflammatory response of periodontium in DPPI-/-mice was less severe than that in WT mice.Conclusion:DPPI may promote the inflammatory response of periodontis in mice.