Synthesis of 10-Position Schiff Base Derivatives of Emodin and Preliminary Investigation of Anti-tumor Ac-tivity in vitro / 中国药师
China Pharmacist
;
(12): 194-196, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-461076
ABSTRACT
Objective:
To synthesize 10-position schiff base derivatives of emodin and study the anti-tumor activity.Methods:
The 10-position schiff base derivatives of emodin were synthesized through emodin reacting with ammonia derivatives in absolute alcohol with acetic acid as the catalytic agent. Their structures were characterized by 1 H-NMR and ESI-MS, and the anti-tumor activity on k562 cells was determined by MTT method.Results:
Three 10-position schiff base derivatives were synthesized and the structures were confirmed, and the IC50 on k562 cells was 4. 5, 3. 8 and 2. 0 μmol·L-1 , respectively.Conclusion:
The 10-position schiff base de-rivatives of emodin can improve the anti-tumor activity and druggability of the parent compound, which are worthy of further study.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Pharmacist
Ano de publicação:
2015
Tipo de documento:
Artigo
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