Dissolution Determination Method for Nisoldipine Tablets / 中国药师

ABSTRACT

Objective:To establish a dissolution determination method for nisoldipine tablets. Methods: The detection was car-ried out according to the second method described in ChP VolumeⅡappendix XC. The medium was 600 ml hydrochloric acid solution (0. 1 mol·L-1 ) containing 0. 05% SDS, the rotation speed was 75 r·min-1 , and the UV detection wavelength was at 238nm. Re-sultsThe linear range of nisoldipine was 4-14 μg·ml-1(r=0. 999 9),and the average recovery was 100. 5%(RSD=1. 1%, n=9). Conclusion:The method is simple, accurate and reliable, and can be used in the dissolution determination of nisoldipine tablets.