Clinicopathologic features of 112 patients with mantle cell lymphoma / 中国肿瘤临床
Chinese Journal of Clinical Oncology
;
(24): 82-86, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-461877
ABSTRACT
Objective:
To explore the clinicopathologic features of 112 patients with mantle cell lymphoma (MCL).Methods:
Da-ta from 112 MCL cases were collected, and immunohistochemical assay was conducted. A break in the CCND1 gene was detected by fluorescence in situ hybridization (FISH). The t-test was used in the statistical analysis.Results:
All tumor cells in the 112 cases ex-pressed B cell-related antigen, including 1 blastoid subtype and 1 polymorphic subtype. Among all the cases, 106 expressed CD5 and 104 expressed cyclinD1. A break in the CCND1 gene was not found in 3 cases with CD5-MCL. IgH/CCND1 polyploid was found in 2 classical cases.Conclusion:
MCL is a type of special immunophenotypic B-cell lymphoma. The prognoses of blastoid and polymorphic subtypes are poor. Special subtypes should be classified during diagnosis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Clinical Oncology
Ano de publicação:
2015
Tipo de documento:
Artigo
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