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Effect of Atorvastatin on Plasma MicroRNA-143/145 Expression in Patients With Stable Angina Pectoris / 中国循环杂志
Chinese Circulation Journal ; (12): 972-975, 2014.
Artigo em Chinês | WPRIM | ID: wpr-462691
ABSTRACT

Objective:

To investigate the effect of atorvastatin on plasma microRNA-143/145 expression in patients with stable angina pectoris (SAP).

Methods:

A total of 74 SAP patients taken atorvastatin at ifrst time were enrolled in this study, the patients were assigned into 2 groups by the dose of medicationLow dose group, the patients received atorvastatin 20 mg/day, n=36 and Moderate dose group, the patients received atorvastatin 40 mg/day, n=38. Plasma levels of LDL-C and microRNA-143/145 were examined before medication and at 1 month, 12 months after medication respectively. The patients were further divided into another 2 groups by plasma levels of LDL-CReach the standard group, plasma LDL-C

Results:

① Compared with baseline condition, plasma levels of microRNA-143/145 were increased in both groups after medication, P0.05.

Conclusion:

Atorvastatin could up-regulate plasma microRNA-143/145 expression, which was not related to lipid-decreasing effect.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Circulation Journal Ano de publicação: 2014 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Circulation Journal Ano de publicação: 2014 Tipo de documento: Artigo